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Indicating that HK cleavage by bacterial supernatants is mainly triggered by the action of plasmin. This was supported when a PKK-deficient plasma was used (Fig. 3E), revealing a cleavage of HK by M49 wild-type supernatant, pSK, and partially by kaolin, but not by the ska supernatant. We further investigated whether SK-activated plasmin is a source of bradykinin release in plasma, and pSK or plasm

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